Scientific Adviser

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Dr Majella Lane, PhD                                                                 

Scientific Adviser in Derma Clinical , Cosmetic and Liposomal Scientist                       


Editor-In-Chief of International Journal of Cosmetic Science, London

http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-2494

Dr Majella lane has written many cosmetic research papers in International Journal of Cosmetic Science. and has research Collaborations with many top cosmetic companies. 

 

Chair of Skin Forum Focus Group, European Union

http://www.skin-forum.eu/

The Academy of Pharmaceutical Sciences

 

Dermafair skin lightening and anti-ageing cream is developed by the world famous Cosmetic Scientist, Dr Majella lane, Editor of the International Journal of Cosmetic Science, London.  

Dr Lane says that she likes to give the very best skin lightening cream which not only lighten the skin but also rejuvenate the skin and the felling of youthful skin.  

http://www.apsgb.co.uk/focus_groups/overview.asp?TeamCode=SK06

 

Dr Majella Lane was educated in Trinity College, Dublin where she obtained her BSc (Pharmacy) and PhD degrees. She has previously held academic posts in Trinity College, Dublin and is a Visiting Scientist at the College of Pharmaceutical Sciences, University of Michigan.

Dr. Lane's areas of expertise include membrane transport, biophysical approaches towards the elucidation of drug-drug, drug-excipient and drug-membrane interactions, mechanisms of drug absorption, transdermal drug delivery, topical drug delivery, percutaneous absorption and buccal absorption. Dr Lane acts as a consultant to a number of pharmaceutical companies and serves on the editorial board of a number of pharmaceutical science journals. Her major research interests are in the development of optimal drug formulations for effective delivery of therapeutics, with special reference to skin and to mucus membranes. Her research group uses a range of biophysical techniques to probe the mechanisms of skin penetration and modulation.

https://www.ema.europa.eu/sites/default/files/ContactsandExperts/p5v3g2_CV.pdf

 

Books

Rathbone, M. J., Hadgraft, J., Roberts, M. S., Lane, M.E. (Eds.) (2008). Modified Release Drug Delivery Technology. (2nd ed.). USA: Informa Healthcare.

Book Chapters

Shah VP, Yacobi A, Lane ME. (2015) Bioequivalence, Quality, and Novel Assessment Technologies for Topical Products: Current Challenges and Future Prospects. In: Topical Drug Bioavailability: Bioequivalence and Penetration, 2ND Edition (Editors V.P. Shah, H.I. Maibach, J. Jenner). Springer. Pages 389-398.

 Xiao P, Abdalghafor H, Lane ME (2014) Membrane solvent penetration measurements using contact imaging. In: Advances in Dermatological Sciences. Volume 1. Pp. 355-360. Royal Society of Chemistry, London.

Lane ME. (2012). Emollients and skin barrier function. In Loden, M., Maibach, H. I. (Eds.). Treatment of Dry Skin Syndrome. The Art and Science of Moisturizers. (pp. 513-524): Springer Heidelberg Dordrecht London.

Nair AB, Hui X, Lane ME, Murthy SN. (2013) In vitro and in vivo models to evaluate topical nail formulations. In:Murthy, S.N., Maibach, H.I. (Eds.). Topical Nail Products and Ungual Drug Delivery. Pp. 123-148. CRC Press. Boca Raton, FL, USA.

Lane ME, Hadgraft J. (2012). Skin permeation assessment: spectroscopic methods. In Benson, H. A. E., Watkinson, A. C. (Eds.). Topical and transdermal drug delivery: principles and practice (pp.155- 166). New York: Wiley.

Lane ME, Santos P, Watkinson AC, Hadgraft J. (2012). Passive skin permeation enhancement. In Benson, H. A. E., Watkinson, A. C. (Eds.). Topical and transdermal drug delivery: principles and practice (pp.23-42). New York: Wiley.

Lane ME, Uchegbu IF, Schatzlein AG. (2010). Nanomedicines from Polymeric Amphiphiles. In Torchilin, V., Amiji, M. M. (Eds.). Handbook of materials for nanoscience (Vol. 1 pp.495-514). Singapore: Pan Stanford Publishing Pte. Ltd.

Cork MJ, Moustafa M, Danby S, Vasilopoulos Y, Tazi-Ahnini R, Ward SJ, Hadgraft, J, Lane ME, Guy RH. (2009). Skin barrier function in atopic dermatitis. In Rawlings, A. V., Leyden, J. J. (Eds.). Skin Moisturization (2nd ed. pp.1-492). New York: Informa Healthcare.

Wiechers JW, Judefeind A, du Plessis J, Kelly CL, Lane ME, Hadgraft J. (2008). The effect of changing the polarity of the stratum corneum on the dermal and transdermal delivery of cosmetically active ingredients. In: Wiechers, J. W. (Ed.). Science and application of skin delivery systems (pp.1- 552). USA: Allured Publishing.

Lane ME, Hadgraft J. (2007). In vitro – in vivo correlations in transdermal drug delivery. In Walters, K. A., Roberts, M. S. (Eds.). Dermal Absorption and Toxicity Assessment (2nd ed. ed. pp.1-600). USA: Informa Healthcare.

 

 Dr Majella Lane's many more research papers at the end of page.

 

Dr Hardyal Gill, PhD                                                                                 

Scientific Adviser in Derma Clinical, Nanotechnology Scientist

Dermafair skin Lightening and skin even tone perfection cream was developed by Dr Hardyal S Gill and Dr Majella Lane, Editor in chief of International Journal of Cosmetic Science and famous in Cosmetics and Liposomal technology.

Dr Hardyal Gill, has many collaborative work with Harley Street in London on Cosmetics while he was developing Dermafair.  Many of the Clinical trials of Dermafair has been done in Harley Street, London. 

Previously worked in UCL and his specialisation is Pharmaceutical Analysis and Nanotechnology specuially Liposomal delivery through skin. 

I am also very thanksful to Dr Majella Lane ,  world famous Cosmetic Scientist and Editor of International Journal of Cosmetic Science for giving advice and guidence throughout Developing Dermafair.  

 

Friends

I am ecstatic to hear that a famous American TV Channel likes to interview me for launching the first Liposomal skin lightening cream in the world. This TV channel interviews people like CEO of Google and APPLE… really Chuffed, can’t wait to go to San Francisco for interview (TV channel based in Bay area, San Francisco).  The interview clip will be posted in our website soon....

https://www.linkedin.com/in/dr-hardyal-gill-aaab8465/detail/recent-activity/shares/

 

 

 

RESEARCH

 

His research is interdisciplinary and he has often collaborated with other academic groups in UCL and from the industry.

  • Liposomes, Nanosome and Ethosomes for skin delivery.
  • Analytical Method Development and to improve existing analytical methods.
  • Validation of analytical methods for API and Impurities by ICH or FDA Guidelines.
  • ICH Guidelines on Impurities in Drug Substances and Drug products.
  • Stability Studies in Finished products by ICH guidelines.

 


https://www.researchgate.net/profile/Hardyal_Gill/

https://www.linkedin.com/in/dr-hardyal-gill-aaab8465/

 

Dr Hardyal Gill has published many papers on Nanotechnology.

Effect Of Storage Conditions On The Photostability Of Dacarbazine

Adu1, H. Gill1, O. Katerina2 I. Ashraf2, *K. Sheikh1 1UCL School of Pharmacy, London, WC1N 1AX, 2Queen’s Hospital, Romford. Initial Abstract communication.


Abida Raza, Akhtar Aman, Shumaila Bashir, Bashir Ahmad, Javaid Irfan, J. Dev Mehta, Hardyal S. Gill, Abad Khan, Mehboob Alam, Andreas G. Schätzlein. Rapid and Sensitive Liquid Chromatographic Method for Determination of Etoposide in Plasma and Biological Samples, Journal of Liquid Chromatography and Related Technologies, Publisher: Taylor & Francis Date: Oct 1, 2013 

Alhalaweh AKaialy WBuckton GGill HNokhodchi AVelaga SP   Theophylline cocrystals prepared by spray drying: physicochemical properties and aerosolization performance. AAPS PharmSciTech. 2013 Mar;14(1):265-76

 

Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC. Purinergic Signal. 2012 Dec;8(4):741-51. Contreras-Sanz AScott-Ward TSGill HSJacoby JCBirch REMalone-Lee JTaylor KMPeppiatt-Wildman CMWildman SS.


Orlu-Gul M, Fisco G, Parmar D, Gill H, Tuleu C. A new reconstitutable oral paediatric hydrocortisone solution containing hydroxypropyl-β-cyclodextrin. Drug Dev Ind Pharm. 2012 Jun 23. [Epub ahead of print] 


Elhissi, A.M.A., Gill, H., Ahmed, W. and Taylor, K.M.G. (2011) Vibrating-mesh nebulization of liposomes generated using an ethanol-based proliposome technology. Journal of Liposome Research, 21 (2). pp. 173-180. 10.3109/08982104.2010.505574.


Shah, T., Tse, A.P.Y., Gill, H., Wong, I.C.K., Sutcliffe, A., Gringras, P., Appleton, R. and Tuleu, C. (2008) Administration of melatonin mixed with common soft food and liquids for children with neurodevelopmental difficulties. Developmental Medcine & Child Neurology, 50 (11). pp. 845-849. 10.1111/j.1469-8749.2008.03092

Elhissi, A.I., Karnam, K., Danesh-Azari, M., Gill, H. and Taylor, K.M.G. (2006) Ethanol-based proliposome formulations for delivery via medical nebulisers. Journal of Pharmacy and Pharmacology, 58 (7). pp. 887-894. 10.1211/jpp.58.7.0002

 

Physical stability and aerosol properties of liposomes delivered using an air-jet nebulizer and a novel micropump device with large mesh apertures International Journal of Pharmaceutics, Volume 334, Issues 1–2, 4 April 2007, Pages 62-70
A.M.A. Elhissi, M. Faizi, W.F. Naji, H.S. Gill, K.M.G. Taylor

Shah, T. and Tse, A.P.Y. and Gill, H. and Wong, I. and Sutcliffe, A. and Gringras, P. and Appleton, R. and Tuleu, C. (2008) Administration of melatonin mixed with common soft food and liquids for children with neurodevelopmental difficulties. Developmental Medcine & Child Neurology, 50 (11). pp. 845-849.

Zahid, N. and Taylor, K.M.G. and Gill, H. and Maguire, F. and Shulman, R. (2008) Adsorption of insulin onto infusion sets used in adult intensive care unit and neonatal care settings. Diabets Research and Clinical Practice, 80 (3). e11-e13.

Heinrich, M. and Rosen, S. and Gill, H. and Feistel, B. and Taylor, K.M.G. (2009) Nasal formulations of a polyphenols-enriched extract of Herba Cisti. Planta Medica, 75 (9). 888. ISSN 0032-0943

Tuleu, C. and Allam, J. and Gill, H. and Yentis, S.M. (2008) Short term stability of pH-adjusted lidocaine-adrenaline epidural solution used for emergency caesarean section. International Journal of Obstetric Anesthesia, 17 (2). pp. 118-122. 

Allam, J. and Gill, H. and Tuleu, C. and Knowlden, P. and Smith, E. and Yentis, S.M. (2007) Short term stability of pH-adjusted lidocaine-adrenaline epidural solution used for emergency caesarean section. In: Obstetric Anaesthesia Annual Meeting, 6th-8th June 2007, Sheffield, UK.

Jakobsson, T. and Shulman, R. and Gill, H. and Taylor, K.M.G. (2009) The impact of insulin adsorption on the infusion sets in the adult intensive care unit. Journal of Diabetes Science and Technology, 3 (1). pp. 213-214.

Buckton, G. and Gill, H. (2007) The importance of surface energetics of powders for drug delivery and the establishment of inverse gas chromatography. Advanced Drug Delivery Reviews, 59 (14). pp. 1474-1479.

 

 

Dr Majella Lane's many more research papers continued...

 

Lane ME, Okumu FW, Balausubramanian P. (2007). Editor of: Injections and implants. In Lane, M.E., Rathbone, M. J., Roberts, M. S., Hadgraft, J. (Eds.). Modified Release Drug Delivery Technology (2nd ed. ed. Vol. 184 pp.123-132). USA: Informa Healthcare.

Lane ME, Hadgraft J. (2013) Penetration enhancers solvents and the skin. In: Fahr, A, Douromis, D. (Eds). Drug delivery strategies for poorly soluble drugs. Wiley, New York. 359-371.

Lane ME, Watkinson AC, Hadgraft J. Editor of: Dermal and Transdermal Drug Delivery. In Lane, M.E., Roberts, M. S., Rathbone, M. J., Hadgraft, J. (Eds.). Modified Release Drug Delivery Technology (2nd ed. ed. Vol. 184 pp.263-272). Informa Healthcare.

Conference Presentations

Machado M, Hadgraft J. Lane ME. (2010). A new model for in vitro finite dose permeation studies. Journal of Pharmacy and Pharmacology. Wiley. (Vol. 62 pp. 1240-1240). Wiley.

Ab Hadi, H., Hadgraft, J., Lane, M.E. (2010). Chemical permeation enhancement strategies for improved topical caffeine delivery. Journal of Pharmacy and Pharmacology. (Vol. 62 pp. 1254-1255). Wiley.

Lane ME, Mader KT, Hadgraft J, Kazarian SG, Tetteh J, McAuley WJ, Andanson JM. (2010). Investigation of skin permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis. Journal of Pharmacy and Pharmacology (Vol. 62 pp. 1279-1280). Wiley.

Lane ME, Chavda SJ, Hadgraft J. (2010). Membrane investigations using biophysical methods and multivariate target factor analysis. Journal of Pharmacy and Pharmacology. (Vol. 62 pp. 1285-1286). Wiley.

Lane ME, Mohammed D, Hadgraft J. (2010). Metrology of the stratum corneum. Journal of Pharmacy and Pharmacology. (Vol. 62 pp.1286-1287). Wiley.

Lane ME, Vieira R., Anissimov Y, Watkinson AC, Hadgraft J. (2010). Modelling of drug permeation in human skin in vitro from finite dose applications. Journal of Pharmacy and Pharmacology. (Vol. 62 pp. 1287-1288). Wiley.

Lane ME, Hadgraft J. Skin: a tortuous problem. (2007). International Journal of Cosmetic Science. (Vol. 29 pp. 224-224. Wiley.

Lane ME, McAuley WJ, Santos P, Hadgraft J. (2006). Determination of the diffusion coefficient of cyanophenol in Carbosil membrane using ATR-FTIR spectroscopy. Journal of Pharmacy and Pharmacology (Vol. 58 pp. A47-A47). Wiley.

Lane ME, Corrigan OI, Levis KA. (2004). Ketoprofen-induced permeability changes in the perfusedrat intestine. AAPS Journal. (Vol. 6 pp. W4282-W4282). Springer.

Lane ME, Corrigan OI, Levis KA. (2004) Comparison of two methods for assessment of druginduced permeability changes. European Journal of Pharmaceutical Sciences. (Vol. 23 pp.52-52). Elsevier

Lane ME, Corrigan OI, Levis KA. (2004). Pharmacokinetics of amino acid derivatives of ibuprofen in the rat. European Journal of Pharmaceutical Sciences. (Vol. 23 pp.70-71). Elsevier.

Lane ME, Corrigan OI., Levis KA. (2004). Effect of ibuprofen on the rat intestinal permeability of GlySar. European Journal of Pharmaceutical Sciences. Elsevier. (Vol. 23 pp. 75-75. Elsevier.

Lane ME, Corrigan OI, Amidon GL, Deasy PB, Landowski CP, Quigley JM. (2004). Synthesis and characterization of arginine derivatives of ibuprofen. AAPS Journal. (Vol. 6 pp. T2290-T2290) Springer.

Lane ME, Corrigan OI, Levis KA. (2003). Dependence of ibuprofen absorption on net intestinal fluid flux in the rat gut. AAPS Pharm Sci. (Vol. 5 pp. R6081-R6081) Springer.

Lane ME, Byrne RS, Deasy PB. The use of pororus aluminosilicate pellets produced by cryopelletization for sustained drug delivery. AAPS Pharm Sci. (Vol. 5 pp. W5096-W5096. 2003

Lane ME, Corrigan OI, Hanlon M, Levis KA, Gilmer JF. (2002). Synthesis and characterisation of arginine derivatives of non-steroidal anti-inflammatory drugs AAPS Pharm Sci. (Vol. 4 pp. R6124-R6124). Springer.

Lane ME, Corrigan OI, O'Driscoll CM, Meaney CM, Gubbins RH. (1998). Correlation between permeability co-efficients in a perfused rat model and the CaCo-2 cell model. European Journal of Pharmaceutical Sciences. (Vol. 6 pp.24-24). Elsevier.

Lane ME, Corrigan OI, O’Driscoll CM. (1998). Calculation of fractions of insulin absorbed and degraded in a perfused rat intestinal model. European Journal of Pharmaceutical Sciences. (Vol. 6 pp. 96-96) Elsevier.

Lane ME, Corrigan OI, O’Driscoll CM. (1998). Effects of protease inhibitors on insulin stability and absorption in the rat intestine. 4th EUFEPS Congress, Milan, 1taly, 11 European Journal of Pharmaceutical Sciences. (Vol. 6 pp. 97-97) Elsevier.

Lane ME, Corrigan OI, O'Driscoll CM. (1998). The effects of bile salt fatty acid mixed micellar systems on insulin stability and absorption in the rat intestine. 17th Pharmaceutical Technology Conference. (Vol. 1 pp.109-120).

Lane ME, Corrigan OI, O'Driscoll CM. (1994). The relationship between molecular size and gastrointestinal permeability. European Journal of Pharmaceutical Sciences. (Vol. 2 pp.187-187). Elsevier.

Journal Articles

Raj N, Voegeli R, Rawlings AV, Doppler S, Imfeld D, Munday MR, Lane ME. (2016) A fundamental investigation into aspects of the physiology and biochemistry of the stratum corneum in subjects with sensitive skin. International Journal of Cosmetic Science. doi: 10.1111/ics.12334.

Parisi N, Paz-Alvarez M, Matts PJ, Lever R, Hadgraft J, Lane ME. (2016). Topical delivery of hexamidine. International Journal of Pharmaceutics 506(1-2): 332-339.

Raj N, Voegeli R, Rawlings AV, Summers B, Munday MR, Lane ME. (2016). Variation in the activities of late stage filaggrin processing enzymes, calpain-1 and bleomycin hydrolase, together with pyrrolidone carboxylic acid levels, corneocyte phenotypes and plasmin activities in non-sun exposed and sun-exposed facial stratum corneum of different ethnicities. International Journal of Cosmetic Science doi: 10.1111/ics.12321.

Raj N, Voegeli R., Rawlings AV, Gibbons S., Munday MR, Summers, B., & Lane, ME. (2016). Variation in stratum corneum protein content as a function of anatomical site and ethnic group. International Journal of Cosmetic Science. 38:224-231.

Hadgraft J, Lane ME. (2016) Drug crystallisation: Implications for topical and transdermal delivery. Expert Opinion on Drug Delivery. DOI:10.1517/17425247.2016.1140146.

Luo L, Patel A, Sinko B, Bell M, Wibawa J, Lane ME. (2016) A comparative study of the in vitro permeation of ibuprofen in mammalian skin, the PAMPA model and silicone membrane. International Journal of Pharmaceutics. 505(1-2):14-19.

Parisi N, Matts PJ, Lever R, Hadgraft J, Lane ME. (2015) Preparation and characterisation of hexamidine salts. International Journal of Pharmaceutics 493(1-2):404-411.

Sattar M, Hadgraft J, Lane ME. Preparation, characterization and buccal permeation of naratriptan. International Journal of Pharmaceutics 493(1-2):146-151.

Kamairudin N, Salwa Abd Gani S, Reza Fard Masoumi H, Basri M, Hashim P, Mohd Mokhtar N, Lane ME. 2015. Modelling of a natural lipstick formulation using an artificial neural network. RSC Advances 5, 68632.

Haque T, Rahman KM, Thurston DE, Hadgraft J, Lane ME. (2015) Topical therapies for skin cancer and actinic keratosis. European Journal of Pharmaceutical Sciences 77:279-89.

Pan W, Zhang X, Lane M, Xiao P. 2015. The occlusion effects in capacitive contact imaging for in vivo skin damage assessments. International Journal of Cosmetic Science 37(4):395-400.

Luo L, Lane ME. (2015) Topical and transdermal delivery of caffeine. International Journal of Pharmaceutics 490(1-2):155-64.

Hadgraft J, Lane ME. (2015) The transdermal delivery of testosterone. European Journal of Pharmaceutics and Biopharmaceutics 92:42-8

Shah VP, Yacobi A, Rădulescu FŞ, Miron DS, Lane ME. 2015. A science based approach to topical drug classification system (TCS). International Journal of Pharmaceutics 491(1-2):21-5.

McAfee DA, Hadgraft J, Lane ME (2014) Rotigotine: The first new chemical entity for transdermal drug delivery. European Journal of Pharmaceutics and Biopharmaceutics 88(3):586-593.

Hirata K, Mohammed D, Hadgraft J, Lane ME. (2014). Influence of lidocaine hydrochloride and penetration enhancers on the barrier function of human skin. International Journal of Pharmaceutics 477 (1-2) 416-20.

Mateus RM, Moore DJ, Hadgraft J, Lane ME. (2014) Percutaneous absorption of salicylic acid – in vitro and in vivo studies. International Journal of Pharmaceutics 475(1-2):471-474.

Goh CF, Lane ME. (2014) Formulation of diclofenac for dermal delivery. International Journal of Pharmaceutics 473(1-2):607-616.

Sattar M, Sayed OM, Lane ME. (2014) Oral transmucosal drug delivery: current status and future prospects. International Journal of Pharmaceutics 471(1-2):498-506.

Xiao P, Abdalghafor HM, Lane ME. 2014 Membrane solvent permeation measurements using contact imaging. Issues in Toxicology 355-60.

Helal F, Lane ME. (2014) Transdermal delivery of Angiotensin Converting Enzyme Inhibitors. European Journal of Pharmaceutics and Biopharmaceutics 88 (1):1-7.

Yacobi A, Shah VP, Bashaw ED, Benfeldt E, Davit B, Ganes D, Ghosh T, Kanfer I, Kasting GB, Katz L, Lionberger RA, Lu GW, Maibach HI, Pershing LK, Rackley RJ, Raw A, Shukla C, Thakker K, Zovko E, Wagner N, Lane ME (2014) Current challenges in bioequivalence, quality and novel assessment technologies for topical products. Pharmaceutical Research 31(4):837-46.

Oliveira G, Leverett JC, Emamzadeh M, Lane ME (2014) The effects of heat on skin barrier function and in vivo dermal absorption. International Journal of Pharmaceutics 464(1-2):145-51.

Mohammed D, Matts PJ, Hadgraft J, Lane ME. (2014) In vitro in vivo correlation in skin permeation. Pharmaceutical Research 31(2):394-400.

Mohammed D, Hirata K, Hadgraft J, Lane ME. (2014) Influence of skin penetration enhancers on skin barrier function and skin protease activity. European Journal of Pharmaceutical Sciences 51(1):118-122.

Watkinson AC, Bunge AL, Hadgraft J, Lane ME. (2013) Nanoparticles do not penetrate human skin – a theoretical perspective. Pharmaceutical Research 30(8): 1943-1946.

Patel A, Bell M, O’Connor C, Inchley A, Wibawa J, Lane ME. (2013) Delivery of ibuprofen to the skin. International Journal of Pharmaceutics 457 (1): 9-13.

Lane ME. (2013) Percutaneous penetration paradigms. Skin Pharmacology and Physiology. 26(4- 6):277-85.

Gorcea, M, Hadgraft, J, Moore, DJ, Lane, ME. (2013) In vivo barrier challenge and long-term recovery in human facial skin. International Journal of Cosmetic Science 19(1) e375-382.

Hirata K, Helal F, Hadgraft J, Lane ME. (2013) Formulation of carbenoxolone for delivery to the skin. International Journal of Pharmaceutics 448(2) 360-5.

Lane ME. (2013) Skin penetration enhancers. International Journal of Pharmaceutics 447 (1-2):12- 21.

Lane ME. (2013) The transdermal delivery of fentanyl. European Journal of Pharmaceutics and Biopharmaceutics. 84(3):449-55.

McAuley WJ, Chavda-Sitaram SJ, Mader KT, Tetteh J, Lane ME, Hadgraft J. (2013) International Journal of Pharmaceutics 447(1-2):1-6.

Gorcea M, Hadgraft J, Moor, DJ, Lane ME. (2013) In vivo barrier challenge and initial recovery in human facial skin. Skin Research and Technology 35(3) 250-56.

Mateus R, Abdalghafor H, Oliveira G, Hadgraft J, Lane ME. (2013) A new paradigm in dermatopharmacokinetics – Confocal Raman Spectroscopy. International Journal of Pharmaceutics 444(1-2):106-8.

Mohammed D, Crowther JM, Matts PJ, Hadgraft J, Lane ME. (2013) Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum. International Journal of Pharmaceutics 441(1-2): 192-201.

Oliveira G, Hadgraft J, Lane ME. (2012) The role of vehicle interactions on permeation of an active through model membranes and human skin. International Journal of Cosmetic Science 34(6):536-45. Gorcea M, Moore DJ, Hadgraft J, Lane ME. (2012). Fourier transform infrared spectroscopy studies of lipid domain formation in normal and ceramide deficient stratum corneum lipid models. International Journal of Pharmaceutics. 435(1) 63-8.

Oliveira G., Hadgraft J., Lane ME. (2012). Toxicological implications of the delivery of fentanyl from gel extracted from a commercial transdermal reservoir patch. Toxicology in vitro. 26(4) 645-8.

Oliveira G, Hadgraft J, Lane ME. (2012). The influence of volatile solvents on transport across model membranes and human skin. International Journal of Pharmaceutics 435(1):38-49.

Mohammed D, Yang Q, Guy RH, Matts PJ, Hadgraft J, Lane ME. (2012) Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping. European Journal of Pharmaceutics and Biopharmaceutics 82(1) 171-4.

Mohammed D, Matts PJ, Hadgraft J, Lane ME. (2012) Variation of stratum corneum biophysical and molecular properties with anatomic site. AAPS Journal 14(4):806-12.

Santos P, Watkinson AC, Hadgraft J, Lane ME. (2012) Influence of penetration enhancer on drug permeation from volatile formulations. International Journal of Pharmaceutics 439(1-2):260-8.

Lane ME, Hadgraft J, Oliveira G, Vieira R, Mohammed D, Hirata K. (2012) Rational formulation design. International Journal of Cosmetic Science 34(6):496-501.

Menon GK, Cleary GW, Lane ME. (2012) The structure and function of the stratum corneum. International Journal of Pharmaceutics 435(1):3-9.

Walters KA, Abdalghafor HM, Lane ME. (2012) The human nail--barrier characterisation and permeation enhancement. International Journal of Pharmaceutics 435(1):10-21.

Mugglestone CJ, Mariz S, Lane ME. (2012) The development and registration of topical pharmaceuticals. International Journal of Pharmaceutics 435(1):22-6.

Lane, ME. (2011). Nanoparticles and the skin applications and limitations. Journal of Microencapsulation 28(8), 709-716

Fredriksen BN, Saevareid K, McAuley L, Lane ME, Bogwald J, Dalmo R. (2011). Early immune responses in Atlantic salmon (Salmo salar L.) after immunization with PLGA nanoparticles loaded with a model antigen and β-glucan. Vaccine 29(46), 8338-8349

Hadgraft J, Lane ME. (2011). Skin: The ultimate interface. Physical Chemistry Chemical Physics 13(12), 5215-5222

Mitragotri S, Anissimov Y, Bunge AL, Frasch H F, Guy RH, Hadgraft J, Lane ME, Kasting G, Roberts MS. (2011). Mathematical models of skin permeability: An overview. International Journal of Pharmaceutics 418(1), 115-129

Mohammed D, Matts PJ, Hadgraft J, Lane ME. (2011). Depth profiling of stratum corneum biophysical and molecular properties. British Journal of Dermatology 164(5), 957-65

Mohammed D, Matts PJ, Hadgraft J, Lane ME. (2011). Influence of Aqueous Cream BP on corneocyte size, maturity, skin protease activity, protein content and transepidermal water loss. British Journal of Dermatology 164(6), 1304-1310

Oliveira G, Beezer AE, Hadgraft J, Lane ME. (2011). Alcohol enhanced permeation in model membranes. Part II. Thermodynamic analysis of membrane partitioning. International Journal of Pharmaceutics 420(2), 216-222

Santos P, Watkinson AC, Hadgraft J, Lane ME. (2011). Enhanced permeation of fentanyl from supersaturated solutions in a model membrane. International Journal of Pharmaceutics 407(1-2), 72- 77

Watkinson RM, Guy RH, Oliveira G, Hadgraft J, Lane M.E. (2011). Optimisation of cosolvent concentration for topical drug delivery III - Influence of lipophilic vehicles on ibuprofen permeation. Skin Pharmacology and Physiology 24(1), 22-26

Xiao P, Imhof RE, Hirata K, McAuley WJ, Mateus R, Hadgraft J, Lane ME. (2011). Opto-Thermal Transient Emission Radiometry (OTTER) to image diffusion in nails in vivo. International Journal of Pharmaceutics 406(1-2), 111-113

Santos P, Watkinson AC, Hadgraft J, Lane ME. (2011). Formulation issues associated with transdermal fentanyl delivery. International Journal of Pharmaceutics 416(1), 155-159

Machado M, Hadgraft J, Lane ME. (2010). Assessment of the variation of skin barrier function with anatomic site, age, gender and ethnicity. International Journal of Cosmetic Science 32(6), 397-409

Machado M, Salgado T, Hadgraft J., Lane M.E. (2010). The relationship between transepidermal water loss and skin permeability. International Journal of Pharmaceutics 384(1-2), 73-77

McAuley WJ, Beezer AE, Oliveira G, Mohammed D, Lane ME. (2010). Thermodynamic considerations of solvent/enhancer uptake into a model membrane. International Journal of Pharmaceutics 396(1-2), 134-139

McAuley W J, Lad MD, Mader KT, Santos P, Tetteh J., Kazarian SG, Hadgraft J, Lane ME. (2010). ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes. European Journal of Pharmaceutics and Biopharmaceutics 74(2), 413-419

Oliveira, G., Beezer, A. E., Hadgraft, J., Lane, M.E. (2010). Alcohol enhanced permeation in model membranes. Part I. Thermodynamic and kinetic analyses of membrane permeation. International Journal of Pharmaceutics 393(1-2), 61-67

Santos P, Watkinson AC, Hadgraft J, Lane ME. (2010). Oxybutynin permeation in skin: The influence of drug and solvent activity. International Journal of Pharmaceutics 384(1-2), 67-72

Zadeh BS, Moghimi HM, Santos P, Hadgraft J., Rahim F, Lane ME. (2010). Formulation of microemulsion systems for improvement of nitrofurazone permeation through silicon membrane as burn wound imitating coverage. International Journal of Pharmacology 6(3), 264-270

Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, Macgowan AL, Tazi-Ahnini R, Guy RH, Ward SJ. (2009). Epidermal barrier dysfunction in atopic dermatitis. Journal of Investigative Dermatology 129(8), 1892-1908

Hadgraft J., Lane ME. (2009). Transepidermal water loss and skin site: A hypothesis. International Journal of Pharmaceutics 373(1-2), 1-3

McAuley WJ, Mader KT, Tetteh J, Hadgraft J, Lane ME. (2009). Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy. European Journal of Pharmaceutical Sciences 38(4), 378-383

Russeau W, Mitchell J, Tetteh J, Lane ME, Hadgraft J. (2009). Investigation of the permeation of model formulations and a commercial ibuprofen formulation in Carbosil® and human skin using ATRFTIR and multivariate spectral analysis. International Journal of Pharmaceutics 374(1-2), 17-25

Santos P, Watkinson AC, Machado M, Hadgraft J, Lane ME. (2009). The effect of drug concentration on solvent activity in silicone membranes. International Journal of Pharmaceutics 377(1-2), 70-75

Tetteh J, Mader KT, Andanson JM, McAuley WJ, Hadgraft J, Lane ME, Kazarian SG, Mitchell J. (2009). Local examination of skin diffusion using FTIR spectroscopic imaging and multivariate target factor analysis. Analytica Chimica Acta 642(1-2), 246-256

Watkinson RM, Guy RH, Hadgraft J, Lane ME. (2009). Optimisation of cosolvent concentration for topical drug delivery - II: Influence of propylene glycol on ibuprofen permeation. Skin Pharmacology and Physiology 22(4), 225-230

Lane ME. (2008). Skin deep delivery. Chemistry and Industry (London) (3), 17-20

Dias M, Naik A, Guy RH, Hadgraft J, Lane ME. (2008). In vivo infrared spectroscopy studies of alkanol effects on human skin. European Journal of Pharmaceutics and Biopharmaceutics 69(3), 1171-1175

Santos P, Watkinson AC, Hadgraft J, Lane ME. (2008). Application of microemulsions in dermal and transdermal drug delivery. Skin Pharmacology and Physiology 21(5), 246-259

Walker, M., Hadgraft, J., Lane, M.E. (2008). Investigation of the permeability characteristics of periulcer and whole ischaemic skin tissue. International Journal of Pharmaceutics 357(1-2), 1-5

Watkinson RM, Oliveira G, Guy RH, Herkenne C, Hadgraft J, Lane ME. (2008). Influence of ethanol on the solubility, ionization and permeation characteristics of ibuprofen in silicone and human skin. Skin Pharmacology and Physiology 22(1), 15-21

Zadeh BS, Moghimi H, Santos P, Hadgraft J, Lane ME. (2008). A comparative study of the in vitro permeation characteristic of sulphadiazine across synthetic membranes and eschar tissue. International Wound Journal 5(5), 633-638

Dias M, Hadgraft J, Lane ME. (2007). Influence of membrane-solvent-solute interactions on solute permeation in skin. International Journal of Pharmaceutics 340(1-2), 65-70

Lane ME, Ita KB, Du Preez J, Hadgraft J, Du Plessis J. (2007). Dermal delivery of selected hydrophilic drugs from elastic liposomes: Effect of phospholipid formulation and surfactants. Journal of Pharmacy and Pharmacology 59(9), 1215-1222

Lane ME, Brennan FS, Corrigan OI. (2006). Influence of post-emulsification drying processes on the microencapsulation of Human Serum Albumin International Journal of Pharmaceutics 307(1), 16-22.

Lane ME, Corrigan OI. (2006). Paracellular and transcellular pathways facilitate insulin permeability in rat gut. Journal of Pharmacy and Pharmacology 58(2), 271-275.

Lane ME, Kim MJ. (2006). Assessment and prevention of gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. Journal of Pharmacy and 58(10), 1295-1304.

Lane ME, Levis KA, Corrigan OI. (2006). Effect of intestinal fluid flux on ibuprofen absorption in the rat intestine. International Journal of Pharmaceutics 309(1-2), 60-66.

Lane ME, Levis KA, McDonald GS, Corrigan OI. (2006). Comparative assessment of two indices of drug induced permeability changes in the perfused rat intestine. International Journal of Pharmaceutics 312(1-2), 196-199.

Lane ME, Dias M, Hadgraft J. (2006). Influence of membrane-solvent-solute interactions on solute permeation in model membranes. International Journal of Pharmaceutics 336(1), 108-114

Lane ME, Hadgraft J. (2006). Passive transdermal drug delivery systems: Recent considerations and advances. American Journal of Drug Delivery 4(3), 153-160

Lane ME, Leveque N, Raghavan SL, Hadgraft J. (2006). Use of a molecular form technique for the penetration of supersaturated solutions of salicylic acid across silicone membranes and human skin in vitro. International Journal of Pharmaceutics 318(1-2), 49-54

Niborski V, Li Y, Brennan F, Lane ME, Torche AM, Remond M, Bonneau M, Riffault S, Stirling C, Hutchings G, Takamatsu H, Barnett P, Charley B., Schwartz-Cornil I. (2006). Efficacy of particle-based DNA delivery for vaccination of sheep against FMDV. 24(49-50), 7204-7213

Lewis G, Coughlan DC, Lane ME, Corrigan OI. (2006). Preparation and release of model drugs from thermally sensitive poly(N-isopropylacrylamide) based macrospheres. Journal of Microencapsulation 23(6), 677-685

Hadgraft J, Lane M.E. (2005). Skin permeation: The years of enlightenment. 305(1-2), 2-12

Lane ME, Brennan FS, Corrigan OI. (2005). Comparison of post-emulsification freeze drying or spray drying processes for the microencapsulation of plasmid DNA. Journal of Pharmacy and Pharmacology 57(7), 831-838.

Lane ME, O'Driscoll CM, Corrigan OI. (2005). Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model. Journal of Pharmacy and 57(2), 169-175.

Shin HC, Landowski CP, Sun D, Lane ME, Vig BS, Kim I, Mittal S, Rosania G, Drach JC, Amidon GL. (2003). Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. Biochemical and Biophysical Research Communications 307(3), 696-703

Levis KA, Lane ME, Corrigan OI. (2003). Effect of buffer media composition on the solubility and effective permeability coefficient of ibuprofen. International Journal of Pharmaceutics 253(1-2), 49-59

Lane ME, Corrigan OI, O'Driscoll CM. (1996). The relationship between rat intestinal permeability and hydrophilic probe size. Pharmaceutical Research 13(10), 1554-1558

Patent

Ward, S. J., Cork, M. J., Davis, A. F., Hadgraft, J., Guy, R. H., Lane, M.E., Macgowan, A. (2007). Pharmaceutical compositions comprising metals for modulating epithelial cell-to-cell adhesion. Patent WO/2007/020479

 

Projects

Elan Pharma (Ireland) PI.  (1998)

Provost’s Academic Development Fund, Trinity College, Dublin. PI.  (1999)

Rice Steele Ltd (Ireland). PI.  (2000)

Fulbright Travel Award Ireland – USA.  (2002)

EPSRC EP/D50273X/1 Co I.  (2005)

Maruho Ltd. (Japan). PI. GB  (2006)

EPSRC Doctoral Training Award. CoI.  (2007)

Portuguese Science Foundation – FCT. PI.  (2007)

Acrux Ltd. (Australia). PI.  (2007)

International Islamic University Malyasia. PI.  (2008)

Procter & Gamble, UK. PI.  (2008)

Croda Ltd., U.K. PI. (2009)

Glaxo Smith Kline, UK PI.  (2009)

ISP Ltd., USA. PI.  (2009).

Higher Education Ministry, Syria. PI (2009).

Shiseido Ltd., Japan. PI.  (2009)

Bloomsbury Studentship, Bloomsbury Colleges. UK PI.  (2009)

British Council Scholarship. PI. (2010)

Dermal Ltd. UK. PI. . (2010)

Procter & Gamble, UK. PI. . (2011)

Higher Education Department. Iraq. PI. (2011)

Dermal Ltd. UK. PI.  (2011)

Higher Education Ministry, Malaysia PI.  (2012)

DSM Ltd. Switzerland PI.  (2012)

Dermal Ltd. UK PI. (2012)

Gojo Ltd. USA PI.  (2013)

Glaxo Smith Kline USA PI.  (2013)

EPSRC Doctoral Training Award UK PI.  (2013)

Phospholipid Research Institute  (2014)

EPSRC Case Award PI.  (2015)

DSM Ltd. Switzerland PI.  (2015)

 

Memberships

Member of the Academy of Pharmaceutical Sciences of Great Britain

Member of the American Association of Pharmaceutical Scientists

Member of the Controlled Release Society

Member of the European Federation for Pharmaceutical Sciences

Member of the United Kingdom-Ireland Controlled Release Society

Secretary and Member of the Skin Forum

Member of the Bioactives Committee of the Society of the Chemical Industry

Member of the Society of Cosmetic Scientists

 

Other Relevant Information

Currently I serve as the Chair of Skin Forum (www.skin-forum.eu) which is an interdisciplinary network of UK scientists who share a common interest in the structure and characterisation of human skin. The forum evolved originally from an EPSRC funded network and is recognised as one of the most influential networks in dermal and cosmetic research today. On behalf of Skin Forum, I have concluded successful negotiations with the Association de Pharmacie Galénique Industrielle (APGI, France) and Arbeitsgemeinschaft für pharmazeutische Verfahrenstechnik (APV, Germany) to run joint meetings in order to establish Skin Forum as a pan-European group. I have also served as programme and scientific chair for these conferences. In January 2006 I was invited to join the Bioactives Committee of the Society of the Chemical Industry (SCI) to develop links between Skin Forum and the SCI. This resulted in a very successful one day meeting and a further event took place in late 2012. I have chaired a number of sessions at the Controlled Release Society’s Annual Meetings, and presented my work at the American Association of Scientists Annual Meeting and the UKPharmSci conference.